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Paper of the Month

  

Die DGHM würdigt jeden Monat DGHM-Mitglieder, die als Erst- oder LetztautorIn an einer herausragenden Publikation, die in den vorangegangenen 3 Monaten hochrangig publiziert wurde, beteiligt waren. Die Forschungsergebnisse können so einer größeren Öffentlichkeit vorgestellt werden.

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Aktuelles Paper of the Month

Identification of immunodominant Bartonella bacilliformis proteins: a combined in silico and serology approach
Alexander A. Dichter, Tilman G. Schultze, Anne Wenigmann, Wibke Ballhorn, Andreas Latz, Elif Schlüfter, Palmira Ventosilla, Humberto Guerra Allison, Cesar A. Ugarte-Gil, Pablo Tsukayama, Volkhard A. J. Kempf*
*korrespondierender Autor

Lancet Microbe 2021, Published Online, September 10, 2021, https://doi.org/10.1016/S2666-5247(21)00184-1

Link zum vollständigen Artikel: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00184-1/fulltext

Erstautor: Alexander Dichter

Original Abstract des Artikels:
Background Bartonella bacilliformis is the aetiological agent of Carrión’s disease, a biphasic and highly lethal illness formerly restricted to the South American Andes that is now spreading to adjacent areas. Reliable serodiagnostic approaches and vaccines are urgently needed. In this study, we aimed to identify immunodominant proteins of B bacilliformis and to establish novel and reliable serodiagnostic tools.

Methods We used a reverse vaccinology approach in combination with an analysis of heterologous genomic expression libraries to identify immunodominant proteins, on the basis of the genome sequences of B bacilliformis strains KC583 and KC584. Antigens were screened with serum samples collected from Peruvian patients with B bacilliformis infections and from German healthy blood donors without history of travel to South America. We further analysed immunoreactive proteins of B bacilliformis with immunoblotting and line blots. We used selected target proteins to develop a diagnostic ELISA. To assess the performance of this ELISA, we did receiver operating characteristic analyses to assess the area under the curve, cutoff values, sensitivities, and specificities with 95% CIs.

Findings We used serum samples obtained between Dec 23, 1990, and May 5, 2018, from 26 Peruvian patients with B bacilliformis infections and serum samples taken between Aug 28 and Aug 31, 2020, from 96 healthy German blood donors. 21 potentially immunodominant proteins were identified and recombinantly expressed, and their reactivity was assessed with immunoblotting and line blots. Of these 21 antigens, 14 were found to be immunoreactive. By using serum samples of Peruvian patients with Carrión’s disease and of healthy German blood donors, we identified three antigens (porin B, autotransporter E, and hypothetical protein B) as suitable immunodominant antigens, and we applied them in a diagnostic ELISA using two different antigen combinations (porin B plus autotransporter E and porin B plus autotransporter E plus hypothetical protein B). For the combination of porin B and autotransporter E, with optical density measured at 450 nm (OD450) cutoff value of 0·29, sensitivity was 80·8% (95% CI 60·7–93·5) and specificity was 94·8% (88·3–98·3) for all Peruvian patient samples. For a combination of porin B, autotransporter E, and hypothetical protein B, with an OD450 cutoff of 0·34, sensitivity was 76·9% (56·4–91·0) and specificity was 93·8% (86·9–97·7) for all Peruvian patient samples.

Interpretation This novel ELISA could represent a useful serodiagnostic tool for future epidemiological studies of B bacilliformis in endemic areas. Additionally, the immunodominant antigens we have identified could provide a first basis for future vaccine development to prevent the highly lethal Carrión’s disease.

Kommentar:
Die Carrión-Krankheit ist eine bakterielle Infektionskrankheit, die im Hochland der südamerikanischen Anden endemisch ist. Der Krankheitserreger Bartonella bacilliformis gelangt durch den Biss von infizierten Sandmücken in die Blutbahn des Menschen und infiziert dort Erythrozyten, wodurch es oftmals zu einer lebensbedrohlichen hämolytischen Anämie kommt. Es wird angenommen, dass asymptomatische B. bacilliformis Infektionen ein Reservoir für neue Ausbrüche darstellen, daher ist die Identifizierung asymptomatischer Träger von besonderer Bedeutung für Seuchenkontrolle. In der hier publizierten Arbeit wurden immundominante B. bacilliformis Proteine erstmals systematisch identifiziert und auf ihre serologische Anwendbarkeit geprüft. Durch Nutzung von B. bacilliformis Genexpressionsbanken in Kombination mit in silico Antigen-Vorhersagen konnten 21 potentielle Antigenkandidaten ermittelt werden. Systematisches Antigen-Screening mit einer qualifizierten B. bacilliformis Serumbank zeigte, dass drei Antigene (autotransporter E, porinB und hypothetical protein B) für die serodiagnostische Nutzung in ELISA Tests geeignet sind. Der hier entwickelte ELISA ermöglicht den Nachweis von IgG Antikörper gegen B. bacilliformis und stellt ein nützliches Werkzeug für die Identifizierung und Prävention neuer tödlicher B. bacilliformis Ausbrüche dar.

Added value of this study
To our best knowledge, this study is one of the first that systematically analysed immunoreactive proteins of B bacilliformis. By combining in-silico and in-vitro approaches, we identified 21 putative antigen candidates. Three of these antigens were successfully applied to serodiagnostic tools (line blots and ELISA), and these were evaluated by using serum samples from patients with Carrión’s disease from one of the best characterised serum libraries.

Implications of all the available evidence
We developed serodiagnostic tools for B bacilliformis infections on the basis of genomic analyses, reverse vaccinology, and recombinant protein expression by using qualified patient serum samples. These assays can detect B bacilliformis antibodies and could be used to gain better understanding of the seroreactivity of particular antigens and of the epidemiology of Carrión’s disease in South America. Furthermore, the detailed analysis of the pattern of immunoreactive antigens through line blots represents a first basis for future development of a vaccine

Korrespondierender Autor:
Prof. Dr. med. Volkhard A. J. Kempf
Universitätsklinikum Frankfurt
Paul-Ehrlich-Str. 40
D-60596 Frankfurt am Main
Telefon: +49 69 6301-5019
Fax: +49 69 6301-83431
Mail: volkhard.kempf @kgu.de

 

September 2021:
Transient Mitochondria Dysfunction Confers Fungal Cross-Resistance against Phagocytic Killing and Fluconazole
Sofía Siscar-Lewin1, Toni Gabaldón2   3   4, Alexander M Aldejohann 5, Oliver Kurzai5, Bernhard Hube1   6, Sascha Brunke 1
mBio, 2021, e0112821 (doi: 10.1128/mBio.01128-21)
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34061590/


Juli/August 2021:
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain
Christine Dunker1 , Melanie Polke1, 2 , Bianca Schulze-Richter1, 3 , Katja Schubert1 , Sven Rudolphi1 , A Elisabeth Gressler1, 3 , Tony Pawlik1 , Juan P Prada Salcedo4 , M Joanna Niemiec1 , Silvia Slesiona-Künzel 1 , Marc Swidergall5 , Ronny Martin6 , Thomas Dandekar 4 , Ilse D Jacobsen7
Nature Communications, 2021, 12:3899 | https://doi.org/10.1038/s41467-021-24095-8
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34162849/

Juni 2021:
NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB
Maurice Diwo#, Wiebke Michel#, Philipp Aurass, Katja Kuhle-Keindorf, Jan Pippel, Joern Krausze, Sabrina Wamp, Christina Lang, Wulf Blankenfeldt*, Antje Flieger*
# and * contributed equally
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2017046118. doi: 10.1073/pnas.2017046118Links zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34074754/

Mai 2021:
The infectious propagules of Aspergillus fumigatus are coated with antimicrobial peptides
Michaela Dümig, Jasmin Binder, Anastasia Gaculenko, Franziska Daul, Lex Winandy, Mike Hasenberg , Matthias Gunzer, Reinhard Fischer, Markus Künzler, Sven Krappmann
Cellular Microbiology 23 (3): e13301;
Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/33331054/

April 2021:
Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells.
Marina Pekmezovic , Hrant Hovhannisyan , Mark S. Gresnigt, Elise Iracane,
João Oliveira-Pacheco, Sofía Siscar-Lewin, Eric Seemann, Britta Qualmann, Till Kalkreuter,
Sylvia Müller, Thomas Kamradt, Selene Mogavero, Sascha Brunke, Geraldine Butler,
Toni Gabaldón  and Bernhard Hube
Nature Microbiology 2021 Mar 22. doi: 10.1038/s41564-021-00875-2.
Link zum vollständigen Artikel: https://www.nature.com/articles/s41564-021-00875-2

März 2021:
Crystal structure of full-length cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication.
Chaoprasid P. #, Lukat P. #, Mühlen S. #, Heidler T., Gazdag EM., Dong S., Bi W., Rüter R., Kirchenwitz M., Steffen A., Jänsch L., Stradal T., Dersch P.*, Wulf Blankenfeldt W.*
#, gemeinsame Erstautoren
*, gemeinsame korrespondierende Autoren
EMBO Journal Jan 7:e105202. doi: 10.15252/embj.2020105202
Link zum vollständigen Artikel: https://www.embopress.org/doi/full/10.15252/embj.2020105202

Februar 2021:
RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio choleraeNikolai Peschek#, Roman Herzog#, Praveen K. Singh#, Marcel Sprenger#, Fabian Meyer, Kathrin S. Fröhlich, Luise Schröger, Marc Bramkamp, Knut Drescher, and Kai Papenfort
# geteilte Erstautorenschaft
Nature Communications 11, 6067 (2020)
Link zum vollständigen Artikel: nature.com/articles/s41467-020-19890-8

Januar 2021:
A Giant Extracellular Matrix Binding Protein of Staphylococcus epidermidis Binds Surface-Immobilized Fibronectin via a Novel Mechanism
Henning Büttner, Markus Perbandt, Thomas Kohler, Alexey Kikhney, Manuel Wolters, Martin Christner, Marisol Heise, Jérôme Wilde, Samira Weißelberg, Anna Both, Christian Betzel, Sven Hammerschmidt, Dmitri Svergun, Martin Aepfelbacher, Holger Rohde.
mBio 2020, Vol. 11, Issue 5
Link zum vollständigen Artikel: https://mbio.asm.org/content/11/5/e01612-20

Dezember 2020:
Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
Riba A, Hassani K, Walker A, van Best N, von Zeschwitz D, Anslinger T, Sillner N, Rosenhain S, Eibach D, Maiga-Ascofaré O, Rolle-Kampczyk U, Basic M, Binz A, Mocek S, Sodeik B, Bauerfeind R, Mohs A, Trautwein C, Kiessling F, May J, Klingenspor M, Gremse F, Schmitt-Kopplin P, Bleich A, Torow N, von Bergen M, Hornef MW
Science Translational Medicine 2020 Oct 14;12(565):eaay7019
Link zum vollständigen Artikel: https://stm.sciencemag.org/content/12/565/eaay7019.full

November 2020:
Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
Franziska Schmidt, Andreas Thywißen, Marie Goldmann, Cristina Cunha, Zoltán Cseresnyés, Hella Schmidt, Muhammad Rafiq, Silvia Galiani, Markus H. Gräler, Georgios Chamilos, João F. Lacerda, António Campos Jr., Christian Eggeling, Marc Thilo Figge, Thorsten Heinekamp, Scott G. Filler, Agostinho Carvalho, Axel A. Brakhage
Cell Reports, 2020, 32(7), 108017
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/32814035

Oktober 2020:

Bile acids drive the newborn’s gut microbiota maturation
N. van Best, U. Rolle-Kampczyk, F. G. Schaap, M. Basic, S. W. M. Olde Damink, A. Bleich, P. H. M. Savelkoul, M. von Bergen, J. Penders, & M. W. Hornef
Nature Communications | (2020)11:3692
Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/32703946/

September 2020: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis
Karthika Rajeeve*, Nadine Vollmuth, Sudha Janaki-Raman , Thomas F Wulff, Apoorva Baluapuri, Francesca R Dejure, Claudia Huber, Julian Fink, Maximilian Schmalhofer, Werner Schmitz , Rajeeve Sivadasan, Elmar Wolf, Wolfgang Eisenreich, Almut Schulze, Jürgen Seibel, Thomas Rudel *
Nature Microbiology, 2020, e pub
Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/32747796/

August 2020: HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis
Gayatri Devraj, Sylvaine Guerit, Jana Seele, Daniel Spitzer, Jadranka Macas, Maryam I. Khel, Roxana Heidemann, Anne K. Braczynski, Wibke Ballhorn1, Stefan Günther, Omolara O. Ogunshola, Michel Mittelbronn, Uwe Ködel, Camelia M. Monoranu, Karl H. Plate, Sven Hammerschmidt, Roland Nau, Kavi Devraj, Volkhard A. J. Kempf*
Acta Neuropathol. doi: 10.1007/s00401-020-02174-2.
Link zum vollständigen Artikel: https://link.springer.com/content/pdf/10.1007%2Fs00401-020-02174-2.pdf

Juli 2020: Contact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards: a cluster-randomised crossover trial
Friederike Maechler, Frank Schwab, Sonja Hansen, Carolina Fankhauser, Stephan Harbarth, Benedikt D Huttner, Cristina Diaz-Agero, Nieves Lopez, Rafael Canton, Patricia Ruiz, Hetty Blok, Marc J Bonten, Fieke Kloosterman, Joost Schotsman, Ben S Cooper, Michael Behnke, Jennifer Golembus, Axel Kola, Petra Gastmeier, on behalf of the R-GNOSIS WP5 study group
Infectious diseases, 2020, 20(5): 575-548
Link zum vollständigen Artikel: https://www.ncbi.nlm.nih.gov/pubmed/32087113

Juni 2020: The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
Matthias I. Gröschel, Conor J. Meehan, Ivan Barilar, Margo Diricks, Aitor Gonzaga, Matthias Steglich, Oscar Conchillo-Solé, Isabell-Christin Scherer, Uwe Mamat, Christian F. Luz, Katrien De Bruyne, Christian Utpatel, Daniel Yero, Isidre Gibert, Xavier Daura, Stefanie Kampmeier, Nurdyana Abdul Rahman, Michael Kresken, Tjip S. van der Werf, Ifey Alio, Wolfgang R. Streit, Kai Zhou, Thomas Schwartz, John W. A. Rossen, Maha R. Farhat, Ulrich E. Schaible, Ulrich Nübel, Jan Rupp, Joerg Steinmann, Stefan Niemann (corresponding Autor) & Thomas A. Kohl
Nat Commun, 2020, 11, 2044.
Link zum vollständigen Artikel: www.nature.com/articles/s41467-020-15123-0

Mai 2020: Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production
Osbelt L1,2, Thiemann S1, Smit N1, Lesker TR1, Schröter M1, Gálvez EJC1,3, Schmidt-Hohagen K4, Pils MC5, Mühlen S6,7, Dersch P6,7, Hiller K4,8, Schlüter D2,9, Neumann-Schaal M10, Strowig T1,3,11. PLoS Pathog. 2020 Mar 24;16(3):e1008448
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/32208465

März/April 2020: Infections caused by extended-spectrum β-lactamase-producing Enterobacterales after rectal colonization with ESBL-producing Escherichia coli or Klebsiella pneumoniae
Denkel LA1, Maechler F1, Schwab F1, Kola A1, Weber A1, Gastmeier P1, Pfäfflin F2, Weber S3, Werner G4, Pfeifer Y4, Pietsch M5, Leistner R6. 2019 Dec 3. 31809805 [Epub ahead of print]
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=31809805

Februar 2020:Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model
Deinhardt-Emmer S1, Rennert K2, Schicke E3, Cseresnyes Z4, Windolph M5, Nietzsche S6, Heller R7, Siwczak F8, Haupt KF9, Carlstedt S8, Schacke M9, Figge MT10, Ehrhardt C9, Loeffler B11, Mosig AS12. Biofabrication. 2020 Jan 27. doi: 10.1088/1758-5090/ab7073.
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=31994489

November 2019:A Chlamydia pneumoniae adhesin induces phosphatidylserine exposure on host cells
Galle JN, Fechtner T, Eierhoff T, Römer W, Hegemann JH.
2019 Oct 11;10(1):4644.
Vollständiger Artikel: www.ncbi.nlm.nih.gov/pubmed/31604911#

Oktober 2019: Oxidative stress drives the selection of quorum sensing mutants in the Staphylococcus aureus population
Shilpa Elizabeth George, Jennifer Hrubesch, Inga Breuing, Naisa Vetter, Natalya Korn, Katja Hennemann, Lisa Bleul, Matthias Willmann, Patrick Ebner, Friedrich Götz, and Christiane Wolz
PNAS, 2019, 116, 19145–19154
Link zur Veröffentlichung: www.ncbi.nlm.nih.gov/pubmed/31488708

September 2019: Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
Bhattacharjee S, Mejías-Luque R, Loffredo-Verde E, Toska A, Flossdorf M, Gerhard M, Prazeres da Costa C.
Cell Rep. 2019 Jul 2;28(1):231-244.e5.
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/31269443

August 2019: MpsAB is important for Staphylococcus aureus virulence and growth under atmospheric CO2 levels
Sook-Ha Fan, Patrick Ebner, Sebastian Reichert, Tobias Hertlein, Susanne Zabel, Aditya Kumar Lankapalli, Kay Nieselt, Knut Ohlsen, Friedrich Götz
Nature Communication  2019 Aug 9;10(1):3627. doi: 10.1038/s41467-019-11547-5.
Link zum vollständigen Artikel: https://www.ncbi.nlm.nih.gov/pubmed/31399577

Juli 2019: Gut Dysbiosis With Bacilli Dominance and Accumulation of Fermentation Products Precedes Late-onset Sepsis in Preterm Infants
Graspeuntner S, Waschina S, Künzel S, Twisselmann N, Rausch TK, Cloppenborg-Schmidt K, Zimmermann J, Viemann D, Herting E, Göpel W, Baines JF, Kaleta C, Rupp J, Härtel C, Pagel.
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/30329017
Clinical Infectious Diseases, Volume 69, Issue 2, 15 July 2019, Pages 268–277

Juni 2019: Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
Herp S#, Brugiroux S#, Garzetti D, Ring D, Jochum LM, Beutler M, Eberl C, Hussain S, Walter S, Gerlach RG, Ruscheweyh HJ, Huson D, Sellin ME, Slack E, Hanson B, Loy A, Baines JF, Rausch P, Basic M, Bleich A, Berry D, Stecher B.   #geteilte Autorenschaft.
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/31006637
Cell Host & Microbe, 2019, Volume (25), Issue 5: 681-694.e8

Mai 2019: A non‐death function of the mitochondrial apoptosis apparatus in immunity
Brokatzky D, Dörflinger B, Haimovici A, Weber A, Kirschnek S, Vier J, Metz A, Henschel J, Steinfeldt T, Gentle IE, Häcker G. Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=30979778
The EMBO Journal; Volume 38, Issue 10

April 2019: Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages
Hayek I, Fischer F, Schulze-Luehrmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A.
Cell Reports, 2019, 26, 3502-3510. Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/30917307

März 2019: Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation
Kessler M, Hoffmann K, Fritsche K, Brinkmann V, Mollenkopf HJ, Thieck O, Teixeira da Costa AR, Braicu EI, Sehouli J, Mangler M, Berger H, Meyer TF.
Nature Communications, 2019, 10(1):1194; Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?te

Februar 2019: Evolution of fluconazole-resistant Candida albicans strains by drug-induced mating competence and parasexual recombination
Christina Popp, Bernardo Ramírez-Zavala, Sonja Schwanfelder, Ines Krüger, Joachim Morschhäuser
mBio, 2019, 10:e02740-18;  Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=30723130

Januar 2019: Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple’s Disease
Moter A*#1,2, Janneck M#3, Wolters M#4, Iking-Konert C3, Wiessner A1,2, Loddenkemper C5, Hartleben B6, Lütgehetmann M4, Schmidt J1,2, Langbehn U6, Janssen S7, Geelhaar-Karsch A7, Schneider T7, Moos V#7, Rohde H#4, Kikhney J#1,2, Wiech T#6.
#geteilte Autorenschaft, *Corrsponding author
Clinical Infectious Diseases, 2018, Oct 22
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=30351371

Dezember 2018: The importance of adjusting for enterococcus species when assessing the burden of vancomycin resistance: a cohort study including over 1000 cases of enterococcal bloodstream infections.
Kramer TS, Remschmidt C, Werner S, Behnke M, Schwab F, Werner G, Gastmeier P, Leistner R
Antimicrobial Resistance & Infection Control 2018; 7:133
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=30459945

November 2018: The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
Kasper L#, König A#, Koenig PA#, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B*
#geteilte Erstautorenschaft, *Corrsponding author
Nature Communication 2018 9(1), 4260
Link zum vollständigen Artikel: www.ncbi.nlm.nih.gov/pubmed/?term=PMC6189146

Oktober 2018: The olfactory epithelium as a port of entry in neonatal neurolisteriosis
Dennis Pägelow, Chintan Chhatbar, Andreas Beineke, Xiaokun Liu, Andreas Nerlich, Kira van Vorst, Manfred Rohde, Ulrich Kalinke, Reinhold Förster, Stephan Halle, Peter Valentin-Weigand, Mathias W. Hornef & Marcus Fulde
Nature Communications, 2018, Oct 15;9(1):4269. doi: 10.1038/s41467-018-06668-2.
Link zum vollständigen Artikel: https://www.ncbi.nlm.nih.gov/pubmed/30323282

September 2018: Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus, Bernadette Geißel, Veronika Loiko, Isabel Klugherz, Zhaojun Zhu, Nikola Wagener, Oliver Kurzai, Cees A. M., J. J. van den Hondel & Johannes Wagener
Nature Communications, 2018, volume 9, Article number: 3098 (2018)
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078979/

August 2018: Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition, Marcus Fulde, Felix Sommer, Benoit Chassaing, Kira van Vorst, Aline Dupont, Michael Hensel, Marijana Basic, Robert Klopfleisch, Philip Rosenstiel, André Bleich, Fredrik Bäckhed, Andrew T. Gewirtz & Mathias W. Hornef
Nature. 2018 Aug 8. doi: 10.1038/s41586-018-0395-5.
Vollständiger Artikel: https://www.nature.com/articles/s41586-018-0395-5

Juli 2018: Candida albicans-induced epithelial damage mediates translocation through intestinal barriers, Stefanie Allert & Toni M. Förster…….. and Bernhard Hube
MBio. 2018 Jun 5;9(3). pii: e00915-18. doi: 10.1128/mBio.00915-18.
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/?term=29871918externer Link

Juni 2018: Chlamydia trachomatis paralyzes neutrophils to evade the host innate immune response, Karthika Rajeeve …….and Thomas Rudel
Nat Microbiol. 2018 Jul;3(7):824-835. doi: 10.1038/s41564-018-0182-y. Epub 2018 Jun 25.
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/?term=29946164externer Link

Mai 2018: Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection, Marion Rother,…..and  Thomas Meyer
Cell Host Microbe. 2018 May 9;23(5):661-671.e8. doi: 10.1016/j.chom.2018.04.002. Epub 2018 Apr 26. Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/?term=29706504externer Link

April 2018: Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo, Zhang K, …….and  Hornef M*.
PloS Pathogens, 2018, 14(3), e1006925
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/29522566

März 2018: CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9, Dugar G, ….and Sharma CM
Molecular Cell, 2018, 69(5):893-905
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/29499139externer Link

Februar 2018: Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus, Becker K, …and Peters G
Emerg Infect Dis 2018 Feb;24(2):242-248. doi: 10.3201/eid2402.171074.
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/29350135externer Link

Januar 2018: Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses, Minh-Thu Nguyen…and Friedrich Götz
t Commun. 2017 Dec 21;8(1):2246. doi: 10.1038/s41467-017-02234-4.
Vollständiger Artikel: https://www.ncbi.nlm.nih.gov/pubmed/29269769externer Link