Die DGHM prämiert Veröffentlichungen, die sich durch eine große Anwendungsrelevanz auszeichnen. Für diese Auszeichnung können Publikationen vorgschlagen werden, an denen ein DGHM-Mitglied als Erst- oder LetztautorIn beteiligt ist und die in den vorangegangenen 3 Monaten hochrangig publiziert wurden.
Aktuelles Highlight der Infektionsprävention und Klin. Mikrobiologie
Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Germany, 2023
Anna Bludau 1,*, Alexander Jack 2,*, Nicole Fischer 3, Johannes Dreesman 4, Christian Drosten 5, Richard Egelkamp 4, Lutz Ehlkes 6, Fabian Feil 4, Adam Grundhoff 7, Hajo Grundmann 8, Pascal Kreuzer 6, Masyar Monazahian 4, Inga Overesch 4, Daniel Schmitt 8, Markus Tröger 2, Alexandra von Reiswitz 9, Jonas Weber 10, Alexander Dilthey 10,*, Claudia Hornberg 2,*, Sandra Reuter 8,*, Simone Scheithauer 1,*
EuroSurveillance, 2025, 30 (13)
Anna Bludau
Link zum vollständigen Artikel: https://pmc.ncbi.nlm.nih.gov/articles/PMC11969963/
Abstract:
Background
Integrated genomic surveillance (IGS), i.e. the integrated analysis of pathogen whole genome sequencing and classical epidemiological data, can contribute substantially to the disease surveillance and infection prevention activities of local public health authorities (LPHAs).
Aim
Our aim was to characterise how LPHAs use IGS, and factors required or important for their implementation, in the context of the German public health system.
Methods
We employed a mixed-methods design combining a quantitative survey of 60 LPHAs in three German states with five qualitative case studies based on LPHAs in four German localities and one state-level public health authority.
Results
Approximately half of LPHAs reported adoption of IGS; applications included outbreak analysis (n = 25), targeting and evaluation of infection control measures (n = 25 and n = 18, respectively) and characterisation of pathogen transmission chains (n = 25). Factors identified as required or important for the implementation of IGS in LPHAs included fast sample-to-result turnaround times, organisational data interpretation capabilities and clearly defined surveillance sampling strategies. Based on the case studies in which the adoption of IGS was successful, we formulate recommendations for implementing IGS at the level of LPHAs, including establishment of dedicated IGS analysis teams within LPHAs, use of user-friendly digital solutions (e.g. browser-based dashboards) for data exchange and analysis, and implementation of IGS in collaboration with local academic institutions.
Conclusion
Our analysis paves the way for increasing the implementation of IGS by LPHAs in Germany and other countries with similarly structured public health systems.
Kommentar:
Die COVID-19-Pandemie hat gezeigt, wie wichtig die genomische Charakterisierung von Krankheitserregern ist, um das Verständnis der Ausbreitung von Krankheiten zu verbessern und Präventionsstrategien gezielter zu gestalten. Gesundheitsämter spielen eine zentrale Rolle bei der Nachverfolgung von Infektionen – ihre Fähigkeit, diese Methoden anzuwenden, ist daher entscheidend.
Wir haben ein Mixed-Methods-Design angewandt, das eine quantitative Umfrage unter 60 Gesundheitsämtern in drei deutschen Bundesländern mit fünf qualitativen Fallstudien in vier deutschen Kommunen und einer staatlichen Gesundheitsbehörde kombiniert. Darunter waren zwei Best-Practice Fallstudien.
Unsere Untersuchung zeigt, dass vielen Gesundheitsämtern Wissen, Ressourcen oder Möglichkeiten fehlen, um genomische Erregersurveillance wirksam einzusetzen. Wir identifizierten zentrale Herausforderungen wie Probenmanagement, Datenauswertung, digitale Tools, Zuständigkeiten, Kommunikation und Finanzierung und entwickelten entsprechende Empfehlungen. Diese bieten einen Fahrplan für den breiteren Einsatz genomischer Erregersurveillance in deutschen Gesundheitsämtern. Universitätskliniken – insbesondere Abteilungen für Infektionsmedizin – können dabei als wichtige Partner dienen, um gemeinsam mit dem Öffentlichen Gesundheitsdienst Strategien nicht nur zur Pandemievorsorge, sondern auch zur generellen Stärkung der Infektionskontrolle zu entwickeln.
Die Studie wurde als Teil des Projektes MolTrax im Rahmen des Netzwerks Universitätsmedizin (NUM2.0) durchgeführt und vom BMBF gefördert (FKZ: 01KX2121).
Kontakt:
Anna Bludau
Universitätsmedizin Göttingen
Georg-August-Universität
Institut für Hygiene und Infektiologie
Robert-Koch-Str. 40, 37075 Göttingen
Email: anna.bludau@med.uni-goettingen.de
Autor:inneninformationen:
1Department of Infection Control and Infectious Diseases, University Medical Center Göttingen, Georg August University Göttingen, Göttingen, Germany
2Bielefeld University, Medical School OWL, Sustainable Environmental Health Sciences, Bielefeld, Germany
3Institute of Medical Microbiology, Virology and Hygiene, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
4Public Health Agency of Lower Saxony, Hanover, Germany
5Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany
6Düsseldorf Health Authority (Gesundheitsamt Düsseldorf), Düsseldorf, Germany
7Leibniz Institute of Virology, Hamburg, Germany
8Institute for Infection Prevention and Control, Medical Center – University of Freiburg, Freiburg, Germany
9Sozialbehörde – Amt für Gesundheit, Hamburg, Germany
10Institute of Medical Microbiology and Hospital Hygiene, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
*These authors contributed equally to this work and share first/last authorship.
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