Die DGHM prämiert Veröffentlichungen, die sich durch eine große Anwendungsrelevanz auszeichnen. Für diese Auszeichnung können Publikationen vorgschlagen werden, an denen ein DGHM-Mitglied als Erst- oder LetztautorIn beteiligt ist und die in den vorangegangenen 3 Monaten hochrangig publiziert wurden.
Aktuelles Highlight der Infektionsprävention und Klin. Mikrobiologie
Molecular surveillance of multidrug-resistant Gram-negative bacteria in Ukrainian patients, Germany, March to June 2022
Autor:innen:
Eurosurveillance, Volume 28, Issue 1, 05/Jan/2023
Link zum vollständigen Artikel: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.1.2200850
Tilman Schultze Claudia Reinheimer
Abstract:
Background:
Since the beginning of the war in Ukraine in February 2022, Ukrainians have been seeking shelter in other European countries.
Aim:
We aimed to investigate the prevalence and the molecular epidemiology of multidrug-resistant Gram-negative (MDRGN) bacteria and meticillin-resistant Staphylococcus aureus (MRSA) in Ukrainian patients at admittance to the University Hospital Frankfurt, Germany.
Methods: We performed screening and observational analysis of all patients from March until June 2022. Genomes of MDRGN isolates were analysed for antimicrobial resistance, virulence genes and phylogenetic relatedness.
Results:
We included 103 patients (median age: 39 ± 23.7 years), 57 of whom were female (55.3%; 95% confidence interval (CI): 45.2–5.1). Patients were most frequently admitted to the Department of Paediatrics (29/103; 28.2%; 95% CI: 19.7–37.9). We found 34 MDRGN isolates in 17 of 103 patients (16.5%; 95% CI: 9.9–25.1). Ten patients carried 21 carbapenem-resistant (CR) bacteria, five of them more than one CR isolate. Four of six patients with war-related injuries carried eight CR isolates. In six of 10 patients, CR isolates caused infections. Genomic characterisation revealed that the CR isolates harboured at least one carbapenemase gene, blaNDM-1 being the most frequent (n = 10). Core genome and plasmid analysis revealed no epidemiological connection between most of these isolates. Hypervirulence marker genes were found in five of six Klebsiella pneumoniae CR isolates. No MRSA was found.
Conclusion:
Hospitals should consider infection control strategies to cover the elevated prevalence of MDRGN bacteria in Ukrainian patients with war-related injuries and/or hospital pre-treatment and to prevent the spread of hypervirulent CR isolates.
Kommentar:
Dies ist die erste molekulargenetisch-epidemiologische Analyse zu multiresistenten gramnegativen Bakterien bei ukrainischen Patienten an einem deutschen Universitätsklinikum. Bei ukrainischen Patienten findet sich eine hohe Prävalenz multiresistenter gramnegativen Bakterien, in erheblichem Anteil mit Carbapenem-Resistenz, sowie das Auftreten hypervirulenter Isolate. Es bedarf einer situations-adaptierten krankenhaushygienischen Strategie, um die Ausbreitung der Pathogene in Kliniken und die hiermit einhergehende Patientengefährdung zu vermeiden.
Kontakt:
Claudia Reinheimer (claudia.reinheimer@kgu.de)
Autor:inneninformationen:
Januar/Februar 2023
Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022 Eurosurveillance, 2022, Volume 27, Issue 50
Link zum vollständigen Artikel: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.50.2200926#html_fulltext
Dezember 2022
The acquisition of transferable extrachromosomal fec operon is associated with a cefiderocol MIC increase in Enterobacterales
Kaan Kocer 1 , Sébastien Boutin 1 2 3 , Klaus Heeg 1 , Dennis Nurjadi 1 3
Journal of Antimicrobial Chemotherapy, 2022 Nov 28;77(12):3487-3495
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/36245258/
Novemver 2022
Virus variant specific clinical performance of SARS-CoV-2 rapid antigen tests in point-of-care use, November 2020 to January 2022
Clinical Microbiology and Infection, 2022
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/36028089/
August/-Oktober 2022
Molecular assessment of Staphylococcus aureus strains in STAT3 Hyper-IgE syndrome patients
Vera Schwierzeck1,2,3 Renate Effner1,2,Felicitas Abel1,2,Matthias Reiger2,5,Gundula Notheis1,2, Jürgen Held6,Valeska Simon7, Sebastian Dintner8, Reinhard Hoffmann7, Beate Hagl1,2, Johannes Huebner4, Alexander Mellmann3,4, Ellen D Renner1,2,9
J Clin Immunol. 2022 Jun 2.
Link zum vollständigen Artikel: link.springer.com/article/10.1007/s10875-022-01293-7
April/Mai 2022
Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition
Elias Eger1 , Michael Schwabe1 , Lukas Schulig2 , Nils-Olaf Hübner3 , Jürgen A Bohnert4 , Uwe T Bornscheuer5 , Stefan E Heiden1 , Justus U Müller1 , Fazal Adnan6 , Karsten Becker4 , Carlos L Correa-Martinez7 , Sebastian Guenther8 , Evgeny A Idelevich4,9 , Daniel Baecker2 , Katharina Schaufler1,10
Microbiology Spectrum, 2022, 18.04.22
Link zum voständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/35435751/
März 2022
A strict mask policy for hospital staff effectively prevents from nosocomial influenza infections and mortality: monocentric data from five consecutive influenza seasons
Ambrosch, Andreas*¹, Luber, Doris¹, Klawonn, Frank2,3 , Kabesch, Michael4,5
J Hospital Infection 2021 Dec 18;121:82-90. doi: 10.1016/j.jhin.2021.12.010
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34929232/
Februar 2022
Molecular Surveillance of Carbapenem-Resistant Gram-Negative Bacteria in Liver Transplant
Candidates
Tilman G. Schultze, Philip G. Ferstl, David Villinger, Michael Hogardt, Wolf O. Bechstein, Stephan Göttig, Thomas A. Wichelhaus, Stefan Zeuzem, Jonel Trebicka, Oliver Waidmann, Martin-Walter Welker* and Volkhard A. J. Kempf*
Front. Microbiol., 22 November 2021
Link zum vollständigen Artikel: https://www.frontiersin.org/articles/10.3389/fmicb.2021.791574/full
Januar 2022
Genomic Investigation and Successful Containment of an Intermittent Common Source Outbreak of OXA-48-Producing Enterobacter cloacae Related to Hospital Shower Drains
Microbiol Spectr 2021 Dec 22;9(3):e0138021
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34817232/
Development and Validation of a Tool for the Prediction of Vancomycin–Resistant Enterococci Colonization Persistence –the PREVENT Score
Christian Boeing , Carlos L Correa-Martinez , Franziska Schuler , Alexander Mellmann , André Karch , Stefanie Kampmeier Microbiology Spectrum, 2021, 9 (2): e00356-21
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34523992/
Surveillance for Colonization, Transmission, and Infection with Methicillin-Susceptible Staphylococcus aureus in a Neonatal Intensive Care Unit
JAMA Network Open. 2021 Sep 1;4(9):e2124938
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34515783/
Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests, and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum
Manuel Krone, Julia Gütling, Johannes Wagener, Thiên-Trí Lâm, Christoph Schoen, Ulrich Vogel, August Stich, Florian Wedekink, Jörg Wischhusen, Thomas Kerkau, Niklas Beyersdorf, Silvana Klingler, Simone Backes, Lars Dölken, Georg Gasteiger, Oliver Kurzai, Alexandra Schubert-Unkmeir
Journal of Clinical Microbiology 2021, 59(8): e00319-21
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/33962959/
Global Distribution Patterns of Carbapenemase-Encoding Bacteria in a New Light: Clues on a Role for Ethnicity
Claudio Neidhöfer1, Christian Buechler1, Guido Neidhöfer2, Gabriele Bierbaum1, Irene Hannet3 , Achim Hoerauf1, Marijo Parčina1
Frontiers in Cellular and Infection Microbiology, 2021, Volume 11, p. 532-550, doi: 10.3389/fcimb.2021.659753
Link zum vollständigen Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276097/
Juli/August 2021
Clinical performance evaluation of SARS-CoV-2 rapid antigen testing in point of care usage in comparison to RT-qPCR
Isabell Wagenhäuser, Kerstin Knies, Vera Rauschenberger, Michael Eisenmann, Miriam McDonogh, Nils Petri, Oliver Andres, Sven Flemming, Micha Gawlik, Michael Papsdorf, Regina Taurines, Hartmut Böhm, Johannes Forster, Dirk Weismann, Benedikt Weißbrich, Lars Dölken, Johannes Liese, Oliver Kurzai, Ulrich Vogel, Manuel Krone
EBioMedicine 2021, 69: 103455
Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/34186490/
Juni2021
Pet husbandry as a risk factor for colonization or infection with MDR organisms: a systematic meta-analysis
J Antimicrob Chemother. 2021 May 12;76(6):1392-1405.doi: 10.1093/jac/dkab058.Link zum vollständigen Artikel: https://pubmed.ncbi.nlm.nih.gov/33864082/
April 2021
Prevalence of SARS-CoV-2 IgG antibodies in a large prospective cohort study of elite football players in Germany (May-June 2020): implications for a testing protocol in asymptomatic individuals and estimation of the rate of undetected cases
(*are joint first authors)
Clinical Microbiology and Infection 202. Mar;27(3):473.e1-473.e4.
Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/33285279/
Januar 2021
“A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition”
Stefan E. Heiden*, Nils-Olaf Hübner*, Jürgen A. Bohnert, Claus-Dieter Heidecke, Axel Kramer, Veronika Balau, Wolfgang Gierer, Stephan Schaefer, Tim Eckmanns, Sören Gatermann, Elias Eger, Sebastian Guenther, Karsten Becker & Katharina Schaufler#
Genome Medicine, 2020, 12:113
Link zum vollständigen Artikel: pubmed.ncbi.nlm.nih.gov/33298160/